Purpose: Respiratory drug delivery has been attracted great interest for the past decades,\nbecause of the high incidence of pulmonary diseases. However, despite its invaluable\nbenefits, there are some major drawbacks in respiratory drug delivery, mainly due to the\nrelatively high drug deposition in undesirable regions. One way to improve the efficiency of\nrespiratory drug delivery through metered-dose inhalers (MDI) is placing a respiratory\nspacer between the inhaler exit and the mouth. The aim of this study was to assess the effect\nof type and shape of spacer on the aerosolization performance of MDIs.\nMethods: A commercial Beclomethasone Dipropionate (BDP) MDI alone or equipped with\ntwo different spacer devices (roller and pear type) widely distributed in the world\npharmaceutical market was used. The effect of spacers was evaluated by calculating\naerosolization indexes such as fine particle fraction (FPF), mass median aerodynamic\ndiameters (MMAD) and geometric standard deviation (GSD) using the next generation\nimpactor.\nResults: Although one of the spacers resulted in superior outcomes than the other one, but it\nwas not statistically significant.\nConclusion: The results confirmed that the type and shape of spacer did not substantially\ninfluence the aerosolization performance of MDIs.
Loading....